Finding shared causal variants between diseases.
925 925 people viewed this event.
We know that there are many genetic loci associated with multiple autoimmune diseases. However demonstrating that a variant is associated with two traits is insufficient to establish causality for both; the true causal variants may be distinct but in linkage disequilibrium. I developed a statistical test to study whether two diseases share distinct or common variants in a given genetic region. By using this algorithm to leverage information across datasets, I was also able to identify novel disease associations.
Additional Details
Speaker (if applicable) -